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KMID : 0191120010160050610
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Journal of Korean Medical Science
2001 Volume.16 No. 5 p.610 ~ p.614
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Is Body Mass Index the Prognostic Factor in Breast Cancer?: A Meta-Analysis
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So Yeon Ryu
Chun-Bae Kim/Chung Mo Nam/Jong Ku Park/Ki Soon Kim/Jong Park/Soo Young Yoo/Kyung Sook Cho
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Abstract
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This study was performed to integrate the results of previous studies that investigated the
relationship between body mass index (BMI) and prognosis in breast cancer. We reviewed the
English literatures using the MEDLINE database from 1966 to 1999. The materials included 12
published articles with a total of 8,029 cases of breast cancer. The effect size was obtained
from hazard ratio in each study. Homogeneity test was conducted before the integration of each
effect size and the result demonstrated that the studies were heterogeneous. A random effect
model was used to integrate the overall effect size. The integrated effect size was 1.56
(95% confidence interval, 1.22-2.00). In addition, publication bias should be accounted for
because each published study was asymmetric in shape revealed by funnel plot. These results
suggest that BMI have a prognostic significance in breast cancer. We believe that well-designed
longitudinal studies, involving a large number of samples are required to resolve these issues.
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KEYWORD
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